programas cribado cancer

Nota bibliográfica cribado c colorrectal 2013-05

Brenner H, Altenhofen L, Stock C, Hoffmeister M. Natural history of colorectal adenomas: Birth cohort analysis among 3.6 million participants of screening colonoscopy. Cancer Epidemiology Biomarkers & Prevention 2013 April 30 DOI:10.1158/1055-9965.EPI-13-0162.

Conclusions: Despite low annual transition rates, cumulative transition rates from advanced adenoma to CRC carriage are expected to exceed 60%, 50% and 40% for age intervals 55-80, 65-80 and 70-80 years, respectively, in both sexes. Cumulative transition rates from non-advanced adenoma to CRC carriage are expected to be close to 30% for age interval 55-80, but less than 2% for age interval 75-80. Impact: Our results enhance the empirical basis for modelling CRC screening strategies.

Senore C, Ederle A, Benazzato L, Arrigoni A, Silvani M, Fantin A, et al. Offering people a choice for colorectal cancer screening. Gut 2013 May;62(5):735-740. DOI:10.1136/gutjnl-2011-301013; 10.1136/gutjnl-2011-301013. PMID:22442162.

CONCLUSIONS: A strategy involving the sequential offer of FS and FIT is a feasible and efficient approach. FIT in people not attending for FS increases screening uptake and detection of advanced adenomas and CRCs.

Castells A, Bessa X, Quintero E, Bujanda L, Cubiella J, Salas D, et al. Risk of Advanced Proximal Neoplasms According to Distal Colorectal Findings: Comparison of Sigmoidoscopy-Based Strategies. Journal of the National Cancer Institute 2013 May 24  DOI:10.1093/jnci/djt117.
Conclusions Whereas the NORCCAP criteria achieved the highest sensitivity for APN detection, the UK recommendations benefited from the lowest number of individuals needed to refer for colonoscopy.

Imperiale TF. Sigmoidoscopy Screening: Understanding the Trade-off Between Detection of Advanced Neoplasia and Diagnostic Efficiency. (editorial). Journal of the National Cancer Institute 2013 May 24 DOI:10.1093/jnci/djt132.

Digby J, Fraser CG, Carey FA, McDonald PJ, Strachan JA, Diament RH, et al. Faecal haemoglobin concentration is related to severity of colorectal neoplasia. J Clin Pathol 2013 May;66(5):415-419.
DOI:10.1136/jclinpath-2013-201445; PMID:23418340.
CONCLUSIONS: f-Hb is related to severity of colorectal neoplastic disease. This has ramifications for the selection of the appropriate cut-off concentration adopted for bowel screening programmes.
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