programas cribado cancer

Nota bibliográfica cribado c colorrectal 2013-07/08

Ladabaum U, Allen J, Wandell M, Ramsey SD. Colorectal Cancer Screening with Blood-Based Biomarkers: Cost-Effectiveness of Methylated Septin 9 DNA vs. Current Strategies. Cancer Epidemiol Biomarkers Prev 2013 Jun 24 DOI:10.1158/1055-9965.EPI-13-0204. PMID:23796793.

Conclusions: mSEPT9 appears to be effective and cost-effective compared with no screening. In order to be cost-effective compared with established strategies, mSEPT9 or blood-based biomarkers with similar test performance characteristics would need to achieve substantially higher uptake and adherence rates than the alternatives. It remains to be proven whether CRC screening with a blood test can improve screening uptake or long-term adherence compared with established strategies. Impact: Our study offer insights into the potential role of CRC screening with blood-based biomarkers.

Pickhardt PJ, Kim DH, Pooler BD, Hinshaw JL, Barlow D, Jensen D, et al. Assessment of volumetric growth rates of small colorectal polyps with CT colonography: a longitudinal study of natural history. The Lancet Oncology 2013 7;14(8):711-720. DOI:

Interpretation Volumetric growth assessment of small colorectal polyps could be a useful biomarker for determination of clinical importance. Advanced adenomas show more rapid growth than non-advanced adenomas, whereas most other small polyps remain stable or regress. Our findings might allow for less invasive surveillance strategies, reserving polypectomy for lesions that show substantial growth. Further research is needed to provide more information regarding the ultimate fate of unresected small polyps without significant growth. Funding.

Hubbard RA, Johnson E, Hsia R, Rutter CM. The cumulative risk of false-positive fecal occult blood test after 10 years of colorectal cancer screening. Cancer Epidemiology Biomarkers & Prevention 2013 July 18 DOI:10.1158/1055-9965.EPI-13-0254.

Conclusions: Most patients participating in annual FOBT screening over 10 years will not have a positive result, reinforcing the potential value of this regimen as a non-invasive alternative to colonoscopy. Impact: Annual stool-based screening is a screening alternative resulting in substantially fewer colonoscopies than once per decade colonoscopy.

Portillo I, Idígoras I, Ojembarrena E, Arana-Arri E, Zubero MB, Pijoán JI, et al. Principales resultados del programa de cribado de cáncer colorrectal en el País Vasco. Gaceta Sanitaria 2013 0;27(4):358-361. DOI:

ResumenObjetivo Describir la estrategia del Programa de Cribado de Cáncer Colorrectal en el País Vasco y los principales resultados de participación en la primera ronda (2009-2011). Método Estudio retrospectivo de las invitaciones realizadas en 2009-2011 y comparación de las tasas de participación y positividad de la prueba de sangre oculta en heces por sexo y grupos de edad. Resultados Se obtuvieron 235.371 invitaciones válidas (personas correctamente localizadas), con una participación media del 64,3% (intervalo de confianza del 95% [IC95%]: 64,1-64,5) y con diferencias significativas (p entre mujeres (67,1%; IC95%: 66,9-67,4) y hombres (61,4%; IC95%: 61,1-61,7). El porcentaje de positivos fue superior (p IC95%: 8,9-9,2) que en las mujeres (4,8%; IC95%: 4,7-4,9). Conclusiones Las tasas de participación en el programa se consideraron adecuadas en comparación con los estudios revisados. Estas tasas podrían estar relacionadas con la estrategia de invitación y con factores culturales y sociales. Objective To describe the procedures of the colorectal cancer screening program in the Basque Country (Spain), and the main results of the first rounds in 2009-2011. Method We carried out a retrospective study of invitations to attend screening between 2009 and 2011. Participation rates and the number of positive results of the fecal occult blood test (FOBT) were analyzed by sex and age group. Results There were 235.371 valid invitations (sent to the correct addresses), with an average participation rate of 64.3% (95%CI: 64.1-64.5%). Significant differences were found (p FOBT results was higher (p 

GISCoR Working Group “Interval cancers and sensitivity estimate”. Detection of the interval cancers and estimate of the sensitivity of colorectal cancer screening programmes. Epidemiol Prev 2013(2-3 suppl).
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